Methanesulfonic Acid → HCID 19968402、化合物

HRID 975834ノート

反応式

HRID 975834 の反応式
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1>CCOCC>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[C:18]3([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[NH:17][CH2:16][CH2:15][CH:14]=2)=[CH:9][CH:8]=1

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 10220867HCID 10220867、化合物

生成物 1

HCID 19968402HCID 19968402、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

A solution of methanesulphonic acid (0.3 g) in ether (15 ml) was added dropwise to a cooled solution of 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene (0.8 g, prepared in a similar manner to that described in Example 14) in ether (25 ml). The resulting solid was collected by filtration, washed with ether and dried in vacuo at ambient temperature to yield 5-(4-chlorophenyl)-1-azaspiro[5.5]undec-4-ene methanesulphonate as a white solid. Yield 1.0 g, mp 226°-231.5° C.

後処理

  1. customprepared in a similar manner to that
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with ether
  4. customdried in vacuo at ambient temperature

出典と根拠

ORDレコード
ord-d9b7f9ce48f04b17b2fb4d4107a9b341
出典データセット
uspto-grants-1997_03
特許番号
US05610161

反応ノート

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