HCID 86750539、化合物 → HCID 57129201、化合物
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]2[CH2:12][CH2:11][CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[N:9]2[C:21](=[O:38])[CH2:22][NH:23][C:24](=[O:37])[NH:25][C:26]2[CH:27]=[C:28]([CH:34]=[CH:35][CH:36]=2)[C:29]([O:31]CC)=[O:30])[CH:5]=[CH:6][CH:7]=1>CO>[OH:1][C:2]1[CH:3]=[C:4]([C@H:8]2[CH2:12][CH2:11][C@@H:10]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=3)[N:9]2[C:21](=[O:38])[CH2:22][NH:23][C:24](=[O:37])[NH:25][C:26]2[CH:27]=[C:28]([CH:34]=[CH:35][CH:36]=2)[C:29]([OH:31])=[O:30])[CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
By proceeding in a fashion similar to that described in Example 9, but starting from 1.8 g of ethyl (2RS,5SR)-3-{3-{2-[2-(3-hydroxyphenyl)-5-(3-methoxyphenyl)-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoate in solution in 30 cm3 of methanol and 0.29 g of potassium hydroxide in solution in 6 cm3 of water and after treatment and recrystallization in diethyl ether, 1 g of (2R*,5S*)-3-{3-{2-[2-(3-hydroxyphenyl)-5-(3-methoxy-phenyl)-1-pyrrolidinyl]-2-oxoethyl}ureido}benzoic acid, melting at 172° C., is obtained.
後処理
- custom0.29 g of potassium hydroxide in solution in 6 cm3 of water and after treatment and recrystallization in diethyl ether