関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chloro-2-methylthiopyrimidine | HCID 97113 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 触媒 | 18-Crown-6 | HCID 28557 | — |
| 溶媒 | Tetraglyme | HCID 8925 | — |
| 生成物 | 4-Fluoro-2-(methylsulfanyl)pyrimidine | HCID 10261244 | 63.1% |
反応手順
To a solution of 35.7 g (0.22 mol) of 4-chloro-2-methylthiopyrimidine (Aldrich Chemical Co., Milwaukee, Wis., USA) in 135 mL of tetraglyme was added 18-crown-6 (1.33 g) and potassium fluoride (Anhydrous, Aldrich Chemical Co., Milwaukee, Wis., USA, 80 g). The mixture was heated at 150° C.with stirring for 16 hours. The mixture was then cooled and distilled under reduced pressure to give 20 g (62%) of 4-fluoro-2-methylthiopyrimidine as a liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07091347B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
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| ORD ID | ord-d02271841a334ff1815f17c48731c924 |
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| 出典メモ | uspto-grants-2006_08 |
|---|
