Hydrochloric Acid → D-Aspartic acid, N-(phenylmethyl)-3-((phenylmethyl)amino)-, (3S)-rel-

HRID 976019ノート

反応式

HRID 976019 の反応式
[C@H:1](Br)([C:7]([OH:9])=[O:8])[C@H:2](Br)[C:3]([OH:5])=[O:4].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.Cl>>[CH2:11]([NH:18][CH:2]([CH:1]([NH:18][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:7]([OH:9])=[O:8])[C:3]([OH:5])=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 6416112,3-Dibromosuccinic acid, meso-

生成物 1

HCID 108349D-Aspartic acid, N-(phenylmethyl)-3-((phenylmethyl)amino)-, (3S)-rel-

反応条件

温度
50 °C

実験手順

To a mechanically stirred solution of meso-2,3-dibromosuccinic acid (27.6 g, 0.100 mol) in alcohol (200 ml) was slowly added benzylamine (85 g, 0.80 mol) at ambient temperature. After complete addition the mixture was refluxed overnight. A heavy precipitate of salts appeared. The mixture was cooled to 50° C. and concentrated hydrochloric acid was added until pH was 4-5. The precipitate was filtered off, washed several times with water and alcohol and dried.

後処理

  1. customat ambient temperature
  2. additionAfter complete addition the mixture
  3. temperaturewas refluxed overnight
  4. filtrationThe precipitate was filtered off
  5. washwashed several times with water and alcohol
  6. customdried

出典と根拠

ORDレコード
ord-6aeed64457d44dbab7339ed680c6b5a5
出典データセット
uspto-grants-1997_03
特許番号
US05610141

反応ノート

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