Water → Cytarabine

HRID 976094ノート

反応式

HRID 976094 の反応式
[CH:1]1[C:15](=[NH:16])[N:14]=[C:13]2[N:3]([C@@H:4]3[O:8][C@H:7]([CH2:9][OH:10])[C@@H:6]([OH:11])[C@@H:5]3[O:12]2)[CH:2]=1.Cl.C(N)(C)(C)C.[OH2:23]>>[CH:1]1[C:15]([NH2:16])=[N:14][C:13](=[O:12])[N:3]([C@@H:4]2[O:8][C@H:7]([CH2:9][OH:10])[C@@H:6]([OH:11])[C@@H:5]2[OH:23])[CH:2]=1

参加物

4

反応物 3

HCID 962WaterHCID 6385Tert-ButylamineHCID 250502,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride

生成物 1

HCID 6253Cytarabine収率 83%

実験手順

2,2'-O-cyclocytidine hydrochloride (6.5 g) was dissolved in 35 mL water at 80° C. The solution was cooled to room temperature and t-butylarnine (2.8 g) was added and the mixture stirred for 2 hours. Thereafter, the solvent was evaporated under vacuum and ethanol (16 g) was added. The mixture was stirred at room temperature for 12 hours. Filtration of the resulting precipitation yielded 5 g of pure cytarabine after drying, which corresponds to a yield of 83%. The product was characterized by comparison of its melting point, and NMR and IR spectra with those previously reported for cytarabine.

後処理

  1. customThereafter, the solvent was evaporated under vacuum and ethanol (16 g)
  2. additionwas added
  3. stirringThe mixture was stirred at room temperature for 12 hours
  4. filtrationFiltration of the resulting precipitation

出典と根拠

ORDレコード
ord-305e6519f328428f83edefa32a2e0332
出典データセット
uspto-grants-1997_03
特許番号
US05610292

反応ノート

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