(E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline → N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)butanoyl]aniline

HRID 976134ノート

反応式

HRID 976134 の反応式
[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([C:17](=[O:34])/[CH:18]=[CH:19]/[CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH2:23][CH2:22]3)=[CH:13][CH:12]=2)=[N:3][CH:2]=1>[Pt]=O.C(O)C>[N:1]1[C:6]2[CH2:7][CH2:8][CH2:9][C:5]=2[C:4]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([C:17](=[O:34])[CH2:18][CH2:19][CH2:20][CH:21]3[CH2:26][CH2:25][N:24]([CH2:27][C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:23][CH2:22]3)=[CH:15][CH:16]=2)=[N:3][CH:2]=1

参加物

4

反応物 1

HCID 19968897(E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline

生成物 1

HCID 19968926N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)butanoyl]aniline収率 78.8%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

30 ml of ethanol and 0.1 g of platinum oxide were added to 0.24 g of (E)-N-(5,6-dihydro-7H-cyclopenta[d]pyrimidin-4-yl)-4-[4-(1-benzylpiperidin-4-yl)-2-butenoyl]aniline, and the mixture was stirred at room temperature under a hydrogen stream for 45 minutes. After removing the solid by filtration, the solvent was removed by distillation and the obtained residue was applied to silica gel column chromatography to obtain 0.19 g of the title compound as white powder.

後処理

  1. customAfter removing the solid
  2. filtrationby filtration
  3. customthe solvent was removed by distillation

出典と根拠

ORDレコード
ord-b1ae639c5410425bb5306b17bc92be40
出典データセット
uspto-grants-1997_03
特許番号
US05610303

反応ノート

読み込み中…