3-(Methylthio)phenyl isocyanate → 1-Cyclohexyl-1-hydroxy-3-[3-(methylthio)phenyl]urea

HRID 976616ノート

反応式

HRID 976616 の反応式
Cl.[CH:2]1([NH:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:10][S:11][C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1>>[CH:2]1([N:8]([OH:9])[C:19]([NH:18][C:14]2[CH:15]=[CH:16][CH:17]=[C:12]([S:11][CH3:10])[CH:13]=2)=[O:20])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 1414183-(Methylthio)phenyl isocyanateHCID 3084432N-Cyclohexylhydroxylamine hydrochloride

生成物 1

HCID 199673931-Cyclohexyl-1-hydroxy-3-[3-(methylthio)phenyl]urea収率 27.1%

実験手順

Using the general method used to prepare Compound 1, N-(cyclohexyl)hydroxylamine hydrochloride (1.5 g, 10 mmol) was reacted with 3-(methylthio)phenyl isocyanate (1.6 g, 10 mmol) to provide 0.76 g of the desired product as a white solid m.p. 147.2°-147.7° C. Analysis: Calculated for C14H20N2O2S: %C, 59.97; %H, 7.19; %N, 9.99; Found: %C, 60.16; %H, 6.95; %N, 9.96.

出典と根拠

ORDレコード
ord-124a20a7d7d74e86aa486b16c45b5783
出典データセット
uspto-grants-1997_03
特許番号
US05612377

反応ノート

読み込み中…