Sodium Dithionite → 2,5,6-Triamino-4-Benzyloxypyrimidine

HRID 976939ノート

反応式

HRID 976939 の反応式
S(S([O-])=O)([O-])=O.[Na+].[Na+].[N:9]([C:11]1[C:12]([NH2:26])=[N:13][C:14]([NH2:25])=[N:15][C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O>O>[NH2:25][C:14]1[N:13]=[C:12]([NH2:26])[C:11]([NH2:9])=[C:16]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:15]=1

参加物

4

反応物 2

HCID 24489Sodium DithioniteHCID 1810292,4-Pyrimidinediamine, 5-nitroso-6-(phenylmethoxy)-

生成物 1

HCID 98160442,5,6-Triamino-4-Benzyloxypyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sodium dithionite is added in portions to a suspension of 17 g 5-nitroso-2,4-diamino-6-benzyloxy-primidine (8) in 300 mL H2O at 50° C. until the red nitroso compound is fully reduced. The free base is separated out by adding aqueous ammonia. The crude product is cooled, suctioned off and crystallized from water, to which activated charcoal and a trace of sodium dithionite is added yielding 9.

後処理

  1. customThe free base is separated out
  2. additionby adding aqueous ammonia
  3. temperatureThe crude product is cooled
  4. customcrystallized from water, to which activated charcoal
  5. additiona trace of sodium dithionite is added
  6. customyielding 9

出典と根拠

ORDレコード
ord-5eed9d62d29b4ff89a5319ce5cc955cb
出典データセット
uspto-grants-1997_03
特許番号
US05612468

反応ノート

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