6-Amino-3-methyl-2-methylsulfanyl-5-nitrosopyrimidin-4-one → 5,6-Diamino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one
反応式
[NH2:1][C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]([CH3:10])[C:4](=[O:11])[C:3]=1[N:12]=O>[NH4+]=S>[NH2:12][C:3]1[C:4](=[O:11])[N:5]([CH3:10])[C:6]([S:8][CH3:9])=[N:7][C:2]=1[NH2:1]参加物
2
実験手順
To 4.0 g (0.02 mole) of 6-amino-3-methyl-2-methylthio-5-nitroso-pyrimidine-4-one (44) was added 40 mL of 20% aqueous ammonium sulfide solution. The mixture was heated under reflux for 30 min. After cooling the precipitate was collected, washed with a little ethanol and dried in a desiccator to give 45 as 2.72 g (75% yield) of colorless crystals (m.p. 211°-212° C.).
後処理
- temperatureThe mixture was heated
- temperatureunder reflux for 30 min
- temperatureAfter cooling the precipitate
- customwas collected
- washwashed with a little ethanol
- customdried in a desiccator
出典と根拠
- ORDレコード
- ord-04ca4354890e41f89c29f6bc0da8aba2
- 出典データセット
- uspto-grants-1997_03
- 特許番号
- US05612468
反応ノート
読み込み中…