Hydrochloric Acid → N-nitro-N-methyl-L-phenylalanine

HRID 977003

反応式

HRID 977003 の反応式
[CH3:1][NH:2][C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl.[N:15]([O-:17])=[O:16].[Na+]>O>[N+:15]([N:2]([CH3:1])[C@H:3]([C:11]([OH:13])=[O:12])[CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)([O-:17])=[O:16]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6951135N-MethylphenylalanineHCID 23668193Sodium Nitrite

生成物 1

HCID 54111718N-nitro-N-methyl-L-phenylalanine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
5 °C

実験手順

N-Methyl-L-phenylalamne (2.50 g) was suspended in water (25 ml) and cone. HCl (1 ml) was addded, with stirring. The solution was cooled to 5° C. and solid sodium nitrite (1.35 g) was added to the stirred solution. After stirring at 5° C. for 1 h, the reaction mixture was partitioned between dichloromethane and water. The organic solution was washed with brine and dried (MgSO4). After filtration the solvent was evaporated to yield N-nitro-N-methyl-L-phenylalanine as a white solid.

後処理

  1. stirringAfter stirring at 5° C. for 1 h
  2. customthe reaction mixture was partitioned between dichloromethane and water
  3. washThe organic solution was washed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationAfter filtration the solvent
  6. customwas evaporated

出典と根拠

ORDレコード
ord-ba84df62857b43a99259d3b989f623be
出典データセット
uspto-grants-1997_03
特許番号
US05612477

関連ノート

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