Triphenylphosphine → Sodium (5R,6S)-2-(5-Ethyl-1-methylpyrazol-3-yl)-6-[(R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate

HRID 977010

反応式

HRID 977010 の反応式
[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH2:10][C@@H:11]3[C@@H:21]([C@H:22]([OH:24])[CH3:23])[C:20](=[O:25])[N:12]3[C:13]=2[C:14]([O:16]CC=C)=[O:15])[CH:4]=1)[CH3:2].C(OCC)(=O)C.ClCCl.C(C(CCCC)C([O-])=O)C.[Na+:45].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CC(C)=O.C(OCC)(=O)C>[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]2[CH2:10][C@@H:11]3[C@@H:21]([C@H:22]([OH:24])[CH3:23])[C:20](=[O:25])[N:12]3[C:13]=2[C:14]([O-:16])=[O:15])[CH:4]=1)[CH3:2].[Na+:45]

参加物

7

反応物 4

HCID 11776TriphenylphosphineHCID 21226138Dichloromethane ethylacetateHCID 23672331Sodium 2-ethylhexanoateHCID 131719868Allyl (5R,6S)-2-(5-Ethyl-1-methylpyrazol-3-yl)-6-[(R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate

生成物 1

HCID 131719869Sodium (5R,6S)-2-(5-Ethyl-1-methylpyrazol-3-yl)-6-[(R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate収率 95%

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 21584569Ethylacetate acetone溶媒

実験手順

Allyl(5R,6S)-2-(5-Ethyl-1-methylpyrazol-3-yl)-6-[(R)-1-hydroxyethyl]carbapen-2-em-3-carboxylate (348 mg) in 1:1 ethyl acetate/dichloromethane (8 ml), under argon was treated successively with sodium 2-ethylhexanoate (198 mg), triphenylphosphine (27 mg) and tetrakis(triphenylphosphine)palladium (0), (38 mg). After a few seconds an off-white precipitate was formed. The reaction mixture was stirred at room temperature for 30 m. T.l.c. analysis (20% acetone/ethyl acetate showed no remaining starting material. The solvents were removed in vacuo and the residual solid stirred with diethyl ether (20 ml). The white solid was filtered off washed with ether and dried. This solid was dissolved in water (10 ml) and chromatographed on HP20SS resin eluting with 1-5% tetrahydrofuran/water (100 ml portions ). The combined fractions containing the product (by h.p.l.c.), were concentrated and freeze-dried to give the title compound as an amorphous pale yellow solid, (3.14 mg, 95%); nmax (KBr) 1755, 1614, 1586 and 1386 cm-1 ; dH (D2O) 1.17 (3H, t, J7.5 Hz), 1.26 (3H, d, J6.4 Hz), 2.56 (2H, q, J7.5 Hz), 3.16 (2H, m), 3.44 (1H, dd, J2.8,6.0 Hz), 3.68 (3H, s), 4.21 (2H, m) and 6.47 (1H, s). m/z (Electrospray) 328 (MH+), 350 (MNa+), 633 (2MNa+, free acid), 655 (2MH+), 677 (22 MNa+).

後処理

  1. customAfter a few seconds an off-white precipitate was formed
  2. customThe solvents were removed in vacuo
  3. stirringthe residual solid stirred with diethyl ether (20 ml)
  4. filtrationThe white solid was filtered off
  5. washwashed with ether
  6. customdried
  7. dissolutionThis solid was dissolved in water (10 ml)
  8. customchromatographed on HP20SS resin
  9. washeluting with 1-5% tetrahydrofuran/water (100 ml portions )
  10. additionThe combined fractions containing the product (by h.p.l.c.)
  11. concentrationwere concentrated
  12. customfreeze-dried

出典と根拠

ORDレコード
ord-0bc829a600ef485ca9fea7caf46145e5
出典データセット
uspto-grants-1997_03
特許番号
US05612477

関連ノート

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