Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate → 4-Methylthiazole-5-carboxylic acid

HRID 977099ノート

反応式

HRID 977099 の反応式
ClC1C=CC([C:8]2[S:9][C:10]([C:14]([O:16]CC)=[O:15])=[C:11]([CH3:13])[N:12]=2)=CC=1[N+]([O-])=O>C(NCC)C>[CH3:13][C:11]1[N:12]=[CH:8][S:9][C:10]=1[C:14]([OH:16])=[O:15]

参加物

3

反応物 1

HCID 19965170Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate

生成物 1

HCID 2098054-Methylthiazole-5-carboxylic acid収率 56%

試薬・触媒・溶媒 1

HCID 8021Diethylamine溶媒

実験手順

Ethyl 2-(4-chloro-3-nitrophenyl)-4-methyl-5-thiazolecarboxylate in diethylamine was heated in the same manner as that of Example 35 and hydrolyzed to give 2-(4-N,N-diethylamino)-3-nitrophenyl)-4-methyl-5-thiazolecarboxylic acid (yield: 56%).

出典と根拠

ORDレコード
ord-485b47014fbb4749a2cbe6fe00189ca3
出典データセット
uspto-grants-1997_03
特許番号
US05614520

反応ノート

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