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Sodium Carbonate → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Hydroxylamine HCl | HCID 21645 | — |
| 反応物 | 3-(4-Cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid | HCID 15340939 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | HCID 131719938 | HCID 131719938 | — |
反応手順
27.9 g of 3-(4-cyanophenyl)-2-oxo-5-oxazolidine carboxylic acid [obtainable according to Example 1] and 26.4 g of hydroxylammonium chloride are boiled for 5 h in a mixture of 750 ml of methanol and 30 ml of water in the presence of 53.4 g of sodium carbonate. The precipitate formed is filtered off with suction, washed with methanol and dried. Treatment with hydrochloric acid gives 3-[4-(amino(hydroxylimino)methyl)phenyl]-2-oxo-5-oxazolidinecarboxylic acid, hydrochloride, m.p. 205°-208°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05614535 |
| 出典データセット | uspto-grants-1997_03 |
| ORD ID | ord-ebafdefec83f481baf0af317c189a8f8 |
| 出典メモ | uspto-grants-1997_03 |