Hydrochloric Acid → 3-(4-Aminomethylphenyl)-2-oxo-5-oxazolidinecarboxylic acid

反応式

C(OC([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([N:16]2[CH2:20][CH:19]([C:21]([OH:23])=[O:22])[O:18][C:17]2=[O:24])=[CH:12][CH:11]=1)=O)(C)(C)C.Cl>CCOCC.O1CCOCC1>[NH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([N:16]2[CH2:20][CH:19]([C:21]([OH:23])=[O:22])[O:18][C:17]2=[O:24])=[CH:14][CH:15]=1

参加物

実験手順

3.36 g of 3-(4-tert-butoxycarbonylaminomethylphenyl)-2-oxo-5-oxazolidinecarboxylic acid [obtainable according to Example 14; m.p. 166°] are stirred at room temperature for 1 h in a mixture of 30 ml of ether and 30 ml of dioxane, which has been saturated beforehand with HCl gas. The precipitate is then filtered off with suction and washed with ether. 3-(4-Aminomethylphenyl)-2-oxo-5-oxazolidinecarboxylic acid is obtained, m.p. 211°-212°.