HCID 19965610、化合物 → HCID 53802020、化合物

反応式

[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([C:13](OC)=[O:14])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][C:2]1[S:6][C:5]([CH2:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]([CH2:13][OH:14])=[CH:11][CH:10]=2)=[N:4][C:3]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

反応物 2

HCID 19965610HCID 19965610、化合物

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 53802020HCID 53802020、化合物

実験手順

Methyl 4-[2-(5-methyl-4-phenyl-2-thiazolyl)ethyl]benzoate was reduced with lithium aluminum hydride in the same manner as in Reference Example 12 to yield 4-[2-(5-methyl-4-phenyl-2-thiazolyl)ethyl]benzyl alcohol, which was then recrystallized from ethyl acetate-hexane to yield colorless prisms having a melting point of 62°-63° C.

出典と根拠

ORDレコード: ord-dada8a92b38a43d780a84e25ddefe149
出典データセット: uspto-grants-1997_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05614544

反応ノート

読み込み中…