Methyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]benzoate → 4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]benzyl alcohol

HRID 977265

反応式

HRID 977265 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][CH2:14][C:15]1[CH:24]=[CH:23][C:18]([C:19](OC)=[O:20])=[CH:17][CH:16]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][OH:20])=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 19965620Methyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]benzoateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 545680024-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethyl]benzyl alcohol

実験手順

Methyl 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]benzoate was reduced with lithium aluminum hydride in the same manner as in Reference Example 12 to yield 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]benzyl alcohol, which was then recrystallized from ethyl acetate-hexane to yield colorless plates having a melting point of 103°-104° C.

出典と根拠

ORDレコード
ord-75b253952b1443f8887904166dc53a19
出典データセット
uspto-grants-1997_03
特許番号
US05614544

関連ノート

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