2-Fluoromethyl-2-phthalimido-5-iodopentanenitrile → 2-Fluoromethyl-2,5-diphthalimidopentanenitrile

HRID 977299ノート

反応式

HRID 977299 の反応式
[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8]I)[C:4]#[N:5].[C:21]1(=[O:31])[NH:25][C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12.[K]>CN(C)C=O>[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8][N:25]1[C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]2[C:21]1=[O:31])[C:4]#[N:5]

参加物

4

反応物 2

HCID 147716572-Fluoromethyl-2-phthalimido-5-iodopentanenitrileHCID 24194345Phthalimide potassium salt

生成物 1

HCID 199663332-Fluoromethyl-2,5-diphthalimidopentanenitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-Fluoromethyl-2-phthalimido-5-iodo-valeronitrile (1.20 g, 3.11 mmol) and potassium phthalimide (0.75 g, 4 mmol) are heated in dimethylformamide (25 mL) to 80° C. for 2 hours. After standing overnight at room temperature, the DMF is removed by vacuum distillation and the residue is dissolved in chloroform and washed with 1N KOH and water. After drying (Na2SO4), evaporation gives 2-fluoromethyl-2,5-diphthalimido-valeronitrile as a solid.

後処理

  1. customthe DMF is removed by vacuum distillation
  2. dissolutionthe residue is dissolved in chloroform
  3. washwashed with 1N KOH and water
  4. customAfter drying
  5. custom(Na2SO4), evaporation

出典と根拠

ORDレコード
ord-967551eef0d04158a459b7d3dbdef65e
出典データセット
uspto-grants-1997_03
特許番号
US05614557

反応ノート

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