1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide → 4-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 977933

反応式

HRID 977933 の反応式
[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([N+:10]([O-])=O)[C:4]([CH3:13])=[N:3]1>CO.[Ni]>[CH3:1][N:2]1[C:6]([C:7]([NH2:9])=[O:8])=[C:5]([NH2:10])[C:4]([CH3:13])=[N:3]1

参加物

4

反応物 1

HCID 12297641,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide

生成物 1

HCID 138229254-amino-1,3-dimethyl-1H-pyrazole-5-carboxamide

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Fifty grams of 1,3-dimethyl-4-nitro-pyrazole-5-carboxamide as prepared in Preparation 2 is dissolved in methanol, 2 g 50% of Raney nickel is added, and the compound is reduced under a hydrogen atmosphere until a 8.15 pound drop in pressure noted. The reaction mixture was filtered, the filtrate concentrated, and the crude material recrystallized in ethyl acetate to yield the product, 1,3-dimethyl-4-amino-pyrazol-5-carboxamide mp 154°-155° C.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customthe crude material recrystallized in ethyl acetate

出典と根拠

ORDレコード
ord-341396783bff4a27abde78b65bb22670
出典データセット
uspto-grants-1987_05
特許番号
US04663326

関連ノート

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