Hydrochloric Acid → 2,4-Piperidinedione, 1-(2-phenylethyl)-
反応式
[CH2:1]([N:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11](C(=O)C)[C:10]1=[O:19])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl>C(O)C>[CH2:1]([N:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH2:11][C:10]1=[O:19])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
4
実験手順
1-Phenethyl-3-acetyl-2,4-dioxopiperidine (5.0 g) and 10% hydrochloric acid (30 ml) are added to ethanol (50 ml), and the mixture is refluxed for 6 hours. After distilling off the solvent, the residue is dissolved in chloroform, and the solution is washed with a saturated sodium chloride solution, dried and then distilled to remove the solvent to give 1-phenethyl-2,4-dioxopiperidine (3.62 g, 86.4%) as an oily substance.
後処理
- temperaturethe mixture is refluxed for 6 hours
- distillationAfter distilling off the solvent
- dissolutionthe residue is dissolved in chloroform
- washthe solution is washed with a saturated sodium chloride solution
- customdried
- distillationdistilled
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-0e59e46561b745debb684ac6e2cd1a5a
- 出典データセット
- uspto-grants-1987_05
- 特許番号
- US04663319
反応ノート
読み込み中…