Hydrochloric Acid → 5-(1-Phenyl-1,2,3,4-tetrazol-5-yl)valeric acid

HRID 978037ノート

反応式

HRID 978037 の反応式
Cl.[C:2]1([N:8]2[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[N:11][N:10]=[N:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O>[C:2]1([N:8]2[C:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[N:11][N:10]=[N:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21295291Methyl 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valerate

生成物 1

HCID 142300655-(1-Phenyl-1,2,3,4-tetrazol-5-yl)valeric acid収率 93.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

20% aqueous Hydrochloric acid (100 ml) is added to methyl 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valerate (9.3 g) and the mixture is refluxed for 4 hours. After cooling, water is added and the mixture is extracted with chloroform. The chloroform solution is extracted with aqueous saturated sodium bicarbonate solution. The aqueous layer is acidified with concentrated hydrochloric acid and again extracted with chloroform. The latter chloroform extract is washed with aqueous saturated sodium chloride solution and dried over magnesium sulfate. Chloroform is distilled off to give 5-(1-phenyl-1,2,3,4-tetrazol-5-yl)valeric acid (8.2 g), pale yollow liquid.

後処理

  1. temperaturethe mixture is refluxed for 4 hours
  2. temperatureAfter cooling
  3. extractionthe mixture is extracted with chloroform
  4. extractionThe chloroform solution is extracted with aqueous saturated sodium bicarbonate solution
  5. extractionagain extracted with chloroform
  6. extractionThe latter chloroform extract
  7. washis washed with aqueous saturated sodium chloride solution
  8. dry with materialdried over magnesium sulfate
  9. distillationChloroform is distilled off

出典と根拠

ORDレコード
ord-0dd8e436b88e42349819a36f4218523c
出典データセット
uspto-grants-1987_05
特許番号
US04663323

反応ノート

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