Diazomethane → Methyl 3-methoxy-1-benzothiophene-2-carboxylate

HRID 978090ノート

反応式

HRID 978090 の反応式
[OH:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].[N+](=[CH2:17])=[N-]>C(Cl)Cl>[CH3:17][O:1][C:2]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8]

参加物

4

反応物 2

HCID 9550Diazomethane2 回HCID 83165Methyl 3-hydroxybenzo[b]thiophene-3-carboxylate

生成物 1

HCID 88021Methyl 3-methoxy-1-benzothiophene-2-carboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A stirred, ice-bath cooled mixture of methyl 3-hydroxybenzo[b]thiophene-2-carboxylate (J. Org. Chem. 32, 2678 (1967) (2.1 g, 0.01 m) and dry methylene chloride (25 ml) was treated with ethereal diazomethane in portions until the yellow color of the diazomethane persists, and nitrogen was no longer evolved. Concentration in vacuo yielded methyl 3-methoxybenzo[b]-thiophene-2-carboxylate as a pale tan solid; m/z 324 (M+.). The material was used without further purification in the next step.

後処理

  1. temperatureA stirred, ice-bath cooled
  2. concentrationConcentration in vacuo

出典と根拠

ORDレコード
ord-944b2aedf42a417992288918ecffac7c
出典データセット
uspto-grants-1987_05
特許番号
US04663344

反応ノート

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