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6-Methyl-1,2,3,4-tetrahydroquinoline → 6-Methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methyl-1,2,3,4-tetrahydroquinoline | HCID 66678 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide maleate | HCID 70406853 | — |
| 生成物 | 6-Methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline | HCID 21297656 | — |
| 生成物 | 1-(2-Aminophenyl)-6-methyl-1,2,3,4-tetra-hydroquinoline | HCID 21299250 | — |
| 生成物 | 5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]-benzodiazepine | HCID 21299254 | — |
反応手順
Starting with 6-methyl-1,2,3,4-tetrahydroquinoline and 2-fluoronitrobenzene and following steps 1a to 1f of Example 2, one may obtain, in sequence, 6-methyl-1-(2-nitrophenyl)-1,2,3,4-tetrahydroquinoline, 1-(2-aminophenyl)-6-methyl-1,2,3,4-tetrahydroquinoline, N-[2-(6-methyl-1-phenyl)-1,2,3,4-tetrahydroquinolin-1-yl]-4-methyl-1-piperazine carboxamide, and 5-methyl-7-(4-methyl-1-piperazinyl)-2,3-dihydro-1H-quino[1,8-ab][1,5]benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04663453 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-45768024532242b3a21c64f0179b32b6 |
| 出典メモ | uspto-grants-1987_05 |