化工社化工社 化学情報印刷レポート · 研究参考用
4-Nitrophenol → benzyloxycarbonyl-L-lysine amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrophenol | HCID 980 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-alpha-Benzyloxycarbonyl-L-lysine | HCID 75172 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | benzyloxycarbonyl-L-lysine amide | HCID 7020264 | — |
反応手順
Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine was dissolved in ethyl acetate and esterified with p-nitrophenol using dicyclohexylcarbodiimide as a coupling agent. Sodium bicarbonate (10%) was added and the product extracted into the organic layer and crystallized from solution, then added to aqueous ammonium hydroxide to form Na -t-butyloxycarbonyl-Ne -benzyloxycarbonyl-L-lysine amide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04665054 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-14bbdd6d54904e618df25400db7d786c |
| 出典メモ | uspto-grants-1987_05 |