Ammonia → 1-(2-Hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole

HRID 978406ノート

反応式

HRID 978406 の反応式
[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH:12][CH2:13][C:14]([F:17])([F:16])[F:15])=S)=[N:5]1.[NH3:18]>CCO>[OH:1][CH2:2][CH2:3][N:4]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH2:18])=[N:12][CH2:13][C:14]([F:17])([F:16])[F:15])=[N:5]1

参加物

4

反応物 2

HCID 222AmmoniaHCID 543739781-(2-Hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole

生成物 1

HCID 212798481-(2-Hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 1-(2-hydroxyethyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole (20.0 g.) in 5N ammonia in EtOH solution (700 ml.) was added yellow mercuric oxide (64.8 g.) with stirring. Stirring was continued for a period of 2 hours. The mixture was filtered through diatomaceous earth and the solvent then evaporated to dryness in vacuo. The residual oil was triturated with ether to give 1-(2-hydroxyethyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole (18.5 g.; 99%), m.p. 82°.

後処理

  1. stirringStirring
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. customthe solvent then evaporated to dryness in vacuo
  4. customThe residual oil was triturated with ether

出典と根拠

ORDレコード
ord-5cc2962a239c4ff3a542d3606234f053
出典データセット
uspto-grants-1987_05
特許番号
US04665073

反応ノート

読み込み中…