Acetone → 1-[2-(Acetylsulfanyl)ethyl]-1,4-dimethylpiperazin-1-ium bromide

HRID 978631

反応式

HRID 978631 の反応式
[S:1]1[CH:5]=[CH:4]C=[C:2]1[CH2:6]C(OCC[Br:12])=O.[CH3:13][N:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1.CC(C)=[O:23]>>[Br-:12].[C:2]([S:1][CH2:5][CH2:4][N+:14]1([CH3:13])[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1)(=[O:23])[CH3:6]

参加物

4

反応物 3

HCID 180AcetoneHCID 78181,4-DimethylpiperazineHCID 570913592-Bromoethyl thiolacetate

生成物 1

HCID 202033661-[2-(Acetylsulfanyl)ethyl]-1,4-dimethylpiperazin-1-ium bromide

反応条件

温度
25 °C

実験手順

A solution of 2-bromoethyl thiolacetate *(2.20 g, 0.012 mol) and 1,4-dimethylpiperazine (1.95 mL, 0.014 mol) in acetone (4 mL) was stirred at 50° C. for 65 h. After cooling to 25° C., the liquid phase was decanted from the gum which was triturated twice in diethyl ether; a hygroscopic yellowish powder, 3.2 g (90%) was obtained; ir (Nujol) νmax : 1685 (C=O of thioester) cm-1 ; 1Hmr (D2O) δ: ##STR141##

後処理

  1. customthe liquid phase was decanted from the gum which
  2. customwas triturated twice in diethyl ether
  3. customa hygroscopic yellowish powder, 3.2 g (90%) was obtained

出典と根拠

ORDレコード
ord-2dce7a7d2c4e4001a1c521cdb3e344ab
出典データセット
uspto-grants-1987_05
特許番号
US04665170

関連ノート

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