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Toluene → Gemfibrozil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 2-Methylpropyl 5-chloro-2,2-dimethylpentanoate | HCID 13913710 | — |
| 反応物 | Sodium 2,5-dimethylphenolate | HCID 23672785 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | Gemfibrozil | HCID 3463 | 80% |
反応手順
subsequently reacting said 2-methylpropyl 5-chloro-2,2-dimethylpentanoate with sodium 2,5-dimethylphenolate under reflux in a solvent comprising a mixture of from 10 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide to 5 parts (V/V) toluene/1 part (V/V) dimethylsulfoxide, hydrolyzing the resulting ester, and thereafter acidifying the mixture and isolating 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04665226 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-236b92105dd24bb1a6f646a20ccc4c94 |
| 出典メモ | uspto-grants-1987_05 |