Ethanol → HCID 13882134、化合物

HRID 978946ノート

反応式

HRID 978946 の反応式
[C:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[N:6]=[CH:5][C:4]=1[C:15]([O:17]CC)=[O:16])#[N:2].[OH-].[K+].C([OH:24])C>O>[C:15]([C:4]1[CH:5]=[N:6][N:7]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:3]=1[C:1]([NH2:2])=[O:24])([OH:17])=[O:16]

参加物

5

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 13772963Ethyl 5-cyano-1-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

生成物 1

HCID 13882134HCID 13882134、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A 2.5 g. portion of ethyl 5-cyano-1-(4-fluorophenyl)-4-pyrazolecarboxylate was combined with 2.6 g. of potassium hydroxide and stirred under reflux in 100 ml. of denatured ethanol for 4 hours. It was then cooled, made acid, diluted with water, and concentrated under vacuum to obtain 2.8 g. of the desired compound, m.p. 232° dec. after recrystallization from acetone. It was identified by elemental analysis.

後処理

  1. temperatureunder reflux in 100 ml
  2. temperatureIt was then cooled
  3. concentrationconcentrated under vacuum
  4. customto obtain 2.8 g
  5. customof the desired compound, m.p. 232° dec. after recrystallization from acetone

出典と根拠

ORDレコード
ord-bcc291f631f343a393519b853a49ba4b
出典データセット
uspto-grants-1987_05
特許番号
US04666504

反応ノート

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