Water → 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

HRID 979083ノート

反応式

HRID 979083 の反応式
[Cl:1][C:2]1[C:15]2[S:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[OH:16].[C:17](Cl)(=[O:19])[CH3:18].C(OCC)(=O)C.O>CN(C=O)C>[C:17]([N:7]1[C:6]2[CH:5]=[CH:4][C:3]([OH:16])=[C:2]([Cl:1])[C:15]=2[S:14][C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)(=[O:19])[CH3:18]

参加物

6

反応物 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 98814184-chloro-3-hydroxy-10H-phenothiazine

生成物 1

HCID 1388203310-acetyl-4-chloro-3-hydroxy-10H-phenothiazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 4-chloro-3-hydroxyphenothiazine (2.2 g) in DMF (10 ml) was added 10 ml of acetyl chloride. The reaction mixture was stirred at ambient temperature for 1 hour. Ethyl acetate was then added, followed by ice and H2O. The organic layer was separated, dried and evaporated. The resulting residue was purified by chromatography on silica gel to give 1.4 g of 10-acetyl-4-chloro-3-hydroxy-10H-phenothiazine (m.p. 214° C.).

後処理

  1. customThe organic layer was separated
  2. customdried
  3. customevaporated
  4. customThe resulting residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-538072a4fc7c40ada44760109d8539a9
出典データセット
uspto-grants-1987_05
特許番号
US04666907

反応ノート

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