Piperidine → Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

HRID 979104ノート

反応式

HRID 979104 の反応式
Cl.Cl[CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[C:18]([CH:19]=1)=[N:17][C:16]1[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22]Cl)[CH:15]=1)[CH:10]=2.[NH:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[N:24]1([CH2:3][CH2:4][O:5][C:6]2[CH:7]=[CH:8][C:9]3[C:18]([CH:19]=2)=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:20][CH2:21][CH2:22][N:17]4[CH2:18][CH2:9][CH2:10][CH2:11][CH2:16]4)[CH:15]=2)[CH:10]=3)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

3

反応物 2

HCID 8082PiperidineHCID 201846653,6-Bis(2-chloroethoxy)acridine hydrochloride

生成物 1

HCID 133712Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

実験手順

A suspension of 3,6-bis(2-chloroethoxy)acridine hydrochloride in piperidine was heated in a steel bomb at 80° C. for 24 hours. The excess piperidine was removed in vacuo and the residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate and filtered. The filtrate was evaporated to a residue, giving 3,6-bis(2-piperidinoethoxy)acridine as yellow crystals, mp 129°-130° C.

後処理

  1. customThe excess piperidine was removed in vacuo
  2. washthe residual solution was washed twice with 30 ml portions of saturated aqueous sodium bicarbonate
  3. filtrationfiltered
  4. customThe filtrate was evaporated to a residue

出典と根拠

ORDレコード
ord-672f57c7110b442d935da12e8fcfa842
出典データセット
uspto-grants-1987_05
特許番号
US04666917

反応ノート

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