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2-Butoxyaniline → Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Butoxyaniline | HCID 138265 | — |
| 反応物 | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate | HCID 13562779 | 60.1% |
反応手順
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (21.5 g) and 2-butoxyaniline (24 g) are added to pyridine (50 ml), and the mixture is refluxed with stirring for 18 hours. The reaction mixture is concentrated to dryness. The residue is recrystallized from DMF to give ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate (20 g). M.p. 209°-211° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04666915 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-c6b4e61da94b46858d0e79b139946c45 |
| 出典メモ | uspto-grants-1987_05 |