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Butyl 4-aminobenzoate → Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Butyl 4-aminobenzoate | HCID 2482 | — |
| 反応物 | Ethyl 4-hydroxy-2-(methylsulfanyl)-5-pyrimidinecarboxylate | HCID 239049 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate | HCID 13562812 | 41.7% |
反応手順
Ethyl 1,6-dihydro-2-methylthio-6-oxo-5-pyrimidinecarboxylate (10 g) and butyl -4-aminobenzoate (10.8 g) are added to ethanol (100 ml), and the mixture is refluxed with stirring for 48 hours. After cooling, the precipitate is collected by filtration and recrystallized from a mixture of DMF and water to give ethyl 1,6-dihydro-2-(4-butoxycarbonylanilino)-6-oxo-5-pyrimidinecarboxylate (7.0 g). M.p. 281°-283° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04666915 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-af91b5896fc74264967fab2191b6c057 |
| 出典メモ | uspto-grants-1987_05 |