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3-Nitrobenzenesulfonic acid → 6-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitrobenzenesulfonic acid | HCID 7387 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 4.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13116741 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-[5-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13370241 | — |
反応手順
20 g of 4.5-dihydro-6-[5-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (EP No. 71 059, Example 1) are stirred under reflux together with 19.5 g of the sodium salt of 3-nitrobenzenesulfonic acid and 13.5 g of sodium hydroxide in b 250 ml of water for 1 hour. Thereafter, while the solution is still hot, acetic acid are added until pH 6.9. The solid material precipitated after cooling is filtered of with suction, washed with water and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04667033 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-8cd74c40b3eb45159312de40f7833fbe |
| 出典メモ | uspto-grants-1987_05 |