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3-Nitrobenzenesulfonic acid → 6-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Nitrobenzenesulfonic acid | HCID 7387 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 4.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13318704 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-[4-(Imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone | HCID 13370246 | — |
反応手順
Analoguous to Example 4, the reaction is carried out with 3 g of 4.5-dihydro-6-[4-(imidazol-1-yl-methyl)-thien-2-yl]-3(2H)-pyridazinone (prepared analoguous to Example 3, m.p. 178° to 179° C.), 2.9 g of the sodium salt of 3-nitrobenzenesulfonic acid and 2 g of sodium hydroxide in 40 ml of water. The reaction mixture is neutralized by the addition of 2.5 ml of acetic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04667033 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-c3b3db63f4814e29a542ad232f754e4d |
| 出典メモ | uspto-grants-1987_05 |