化工社化工社 化学情報印刷レポート · 研究参考用
Sodium borohydride → 1-Nitrohexane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Boron | HCID 5462311 | — |
| 反応物 | O-acetyl-1-(3,4-dimethoxyphenyl)-2-nitro-6-cyano-6-(i-propyl)-6-(3,4-dimethoxyphenyl)hexan-3-ol | HCID 13745755 | — |
| 反応物 | Nitrohexanol acetate | HCID 88666005 | — |
| 生成物 | 1-Nitrohexane | HCID 12589 | — |
| 生成物 | 1-(3,4-Dimethoxyphenyl)-2-nitro-6-cyano-6-(prop-2-yl)-6-(3,4-dimethoxyphenyl)hexane | HCID 13745756 | — |
反応手順
The resulting nitrohexanol acetate of formula 9 is then reduced using a boron-based reducing agent, e.g., sodium borohydride, in a 2° or 3° alkanol at 25°-80° C. for 3-15 hours to produce a nitrohexane derivative of formula 10 (step 8). For example, O-acetyl-1-(3,4-dimethoxyphenyl)-2-nitro-6-cyano-6-(i-propyl)-6-(3,4-dimethoxyphenyl)hexan-3-ol (9) is heated with NaBH4 in 2-propanol at reflux for 3-15 hours to yield 1-(3,4-dimethoxyphenyl)-2-nitro-6-cyano-6-(prop-2-yl)-6-(3,4-dimethoxyphenyl)hexane (10).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04667038 |
| 出典データセット | uspto-grants-1987_05 |
| ORD ID | ord-b7b53369e9204aa3b82b35534c61639f |
| 出典メモ | uspto-grants-1987_05 |