Triethylamine → 1-(4-Chlorobutoxymethyl)-2-bromo-4,5-dichloroimidazole

HRID 979511ノート

反応式

HRID 979511 の反応式
[Br:1][C:2]1[NH:3][C:4]([Cl:8])=[C:5]([Cl:7])[N:6]=1.C(N(CC)CC)C.[Cl:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][CH2:22]Cl>C1(C)C=CC=CC=1>[Cl:16][CH2:17][CH2:18][CH2:19][CH2:20][O:21][CH2:22][N:3]1[C:4]([Cl:8])=[C:5]([Cl:7])[N:6]=[C:2]1[Br:1]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 994842-Bromo-4,5-dichloro-1H-imidazoleHCID 3146301-Chloro-4-(chloromethoxy)butane

生成物 1

HCID 137726871-(4-Chlorobutoxymethyl)-2-bromo-4,5-dichloroimidazole収率 35.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a mixture of 1.08 g of 2-bromo-4,5-dichloroimidazole, 0.51 g of triethylamine and about 30 ml of toluene was added dropwise 0.79 g of 4-chlorobutoxymethyl chloride at room temperature, and the resulting mixture was stirred at room temperature for 2 hours. The deposited crystal was filtered off and washed with about 10 ml of toluene. The filtrate thus obtained was concentrated under reduced pressure, and the residual oily product was purified by column chromatography on silica gel to obtain 0.60 g of 1-(4-chlorobutoxymethyl)-2-bromo-4,5-dichloroimidazole.

後処理

  1. filtrationThe deposited crystal was filtered off
  2. washwashed with about 10 ml of toluene
  3. customThe filtrate thus obtained
  4. concentrationwas concentrated under reduced pressure
  5. customthe residual oily product was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-4b56f2c78ab2487fb6f83b09156286ee
出典データセット
uspto-grants-1987_05
特許番号
US04668693

反応ノート

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