Sodium Methoxide → 1-[4-(2-Methoxyethoxy)phenyl]methanamine

HRID 979786ノート

反応式

HRID 979786 の反応式
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1.[CH3:13][O-:14].[Na+]>C1(C)C=CC=CC=1.CO>[CH3:13][O:14][CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 202228754-(2-Chloroethoxy)benzylamine

生成物 1

HCID 202228351-[4-(2-Methoxyethoxy)phenyl]methanamine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 1140Toluene溶媒

実験手順

4-(2-Chloroethoxy)benzylamine (2.0 g; 0,11 mol) was dissolved in anhydrous toluene (50 ml). The reaction mixture was ice-cooled and sodium methoxide (0.59 g; 0.011 mol) dissolved in methanol (5 ml) was added thereto. When the addition was complete the mixture was left to stand for 2 hours at room temperature and filtered. Solvent was evaporated from the filtrate, to give an oily residue of good purity.

後処理

  1. temperaturecooled
  2. additionwas added
  3. additionWhen the addition
  4. waitwas left
  5. filtrationfiltered
  6. customSolvent was evaporated from the filtrate
  7. customto give an oily residue of good purity

出典と根拠

ORDレコード
ord-af266a91e9b84dd09eeb033e3f4830d6
出典データセット
uspto-grants-1987_01
特許番号
US04634701

反応ノート

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