HCID 13755489、化合物 → 1-(4-Oxocyclohexyl)imidazolidin-2-one

HRID 979903ノート

反応式

HRID 979903 の反応式
N[CH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH2:4][CH2:3]1.Cl[O-:15].[K+]>[Cl-].C([N+](CCCC)(CCCC)CCCC)C1C=CC=CC=1.C(OCC)(=O)C>[O:15]=[C:2]1[CH2:7][CH2:6][CH:5]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH2:4][CH2:3]1

参加物

5

反応物 2

HCID 13755489HCID 13755489、化合物HCID 23665762Potassium hypochlorite

生成物 1

HCID 202230821-(4-Oxocyclohexyl)imidazolidin-2-one

試薬・触媒・溶媒 2

HCID 159952Benzyltributylammonium chloride触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 18.3 g of 1-(4-aminocyclohexyl)-2-imidazolidinone as a mixture of cis and trans isomers, 2.0 g of benzyltributylammonium chloride, 250 ml of ethyl acetate and 360 ml of an aqueous 10% potassium hypochlorite solution [according to methodology as described by C. A. Meyers, J. Org. Chem. 26, 1046 (1961)] is stirred at room temperature for 11/2 hours. The organic layer is separated and the aqueous layer is extracted with ethyl acetate. The pooled organic phases are washed with water, sodium bicarbonate solution and dilute hydrochloric acid, then dried and evaporated to dryness to yield 1-(4-oxocyclohexyl)-2-imidazolidinone.

後処理

  1. customThe organic layer is separated
  2. extractionthe aqueous layer is extracted with ethyl acetate
  3. washThe pooled organic phases are washed with water, sodium bicarbonate solution and dilute hydrochloric acid
  4. customdried
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-9fd8a531d3e44da2bc425bc004f22739
出典データセット
uspto-grants-1987_01
特許番号
US04634713

反応ノート

読み込み中…