Sodium Acetate → 3-Methylflavone-8-carboxylic acid

HRID 979991ノート

反応式

HRID 979991 の反応式
Cl[C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([OH:14])=[O:13])[CH:11]=1)[O:8][C:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[C:6]([CH3:21])[C:5]2=[O:22].C([O-])(=O)C.[Na+].[H][H]>[C].[Pd].C(O)(C)C>[CH3:21][C:6]1[C:5](=[O:22])[C:4]2[C:9](=[C:10]([C:12]([OH:14])=[O:13])[CH:11]=[CH:2][CH:3]=2)[O:8][C:7]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

6

反応物 3

HCID 517045Sodium AcetateHCID 133359856-Chloro-3-methylflavone-8-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 770163-Methylflavone-8-carboxylic acid収率 93%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 3776Isopropanol溶媒

実験手順

Into a pressure reactor were placed 3.15 g (0.01 mole) of 6-chloro-3-methylflavone-8-carboxylic acid, 4.0 g (0.03 mole) of sodium acetate, 150 ml of isopropanol and 0.2 g of 5% palladium-carbon catalyst. After the atmosphere was replaced with hydrogen gas, reaction was performed at a pressure of 5.0 kg/cm2G at 70° C. for 6 hours. Then the reaction mixture was treated in the same manner as in Example 13, affording 2.6 g (93%) of 3-methylflavone-8-carboxylic acid which was recrystallized from alcohol, giving a product melting at 230° to 233° C.

後処理

  1. customInto a pressure reactor were placed
  2. additionThen the reaction mixture was treated in the same manner as in Example 13

出典と根拠

ORDレコード
ord-b089bcf4f26242ca82a05a8991d29264
出典データセット
uspto-grants-1987_01
特許番号
US04634768

反応ノート

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