Potassium Hydroxide → 3-Methylflavone-8-carboxylic acid

HRID 979992ノート

反応式

HRID 979992 の反応式
[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([O:15]C)=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[OH-].[K+]>CO>[CH3:1][C:2]1[C:11](=[O:12])[C:10]2[C:5](=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[CH:8][CH:9]=2)[O:4][C:3]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 7582698Methyl 3-methylflavone-8-carboxylate

生成物 1

HCID 770163-Methylflavone-8-carboxylic acid収率 97.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A 29.4 g (0.10 mole) quantity of methyl 3-methylflavone-8-carboxylate was added to 200 ml of a solution of 0.5N--KOH in methanol. The mixture was refluxed with heating for 3 hours and the solvent was removed by distillation. To the residue was added 300 ml of water to dissolve the residue in water and the solution was subjected to filtration. The filtrate was neutralized with dilute hydrochloric acid to give 27.3 g (97.5%) of 3-methylflavone-8-carboxylic acid, M.P. 229° to 231.5° C.

後処理

  1. temperatureThe mixture was refluxed
  2. temperaturewith heating for 3 hours
  3. customthe solvent was removed by distillation
  4. additionTo the residue was added 300 ml of water
  5. dissolutionto dissolve the residue in water
  6. filtrationthe solution was subjected to filtration

出典と根拠

ORDレコード
ord-6b3791617d64429aa20603dd4c29522d
出典データセット
uspto-grants-1987_01
特許番号
US04634768

反応ノート

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