Sulfate Ion → N-(2-((2-hydroxy-3-(4-(2-methoxyethoxy)phenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide

HRID 980159ノート

反応式

HRID 980159 の反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:16]=[CH:15][C:9]([O:10][CH2:11][CH:12]2[O:14][CH2:13]2)=[CH:8][CH:7]=1.S([O-])([O-])(=O)=O.[NH2:22][CH2:23][CH2:24][NH:25][C:26]([N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=[O:27].C([O-])([O-])=O.[K+].[K+]>CC(O)C>[OH:14][CH:12]([CH2:11][O:10][C:9]1[CH:15]=[CH:16][C:6]([O:5][CH2:4][CH2:3][O:2][CH3:1])=[CH:7][CH:8]=1)[CH2:13][NH:22][CH2:23][CH2:24][NH:25][C:26]([N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1)=[O:27]

参加物

6

反応物 4

HCID 1117Sulfate IonHCID 11430Potassium CarbonateHCID 11041198N-(2-Aminoethyl)-4-morpholinecarboxamideHCID 126215491-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene

生成物 1

HCID 20222106N-(2-((2-hydroxy-3-(4-(2-methoxyethoxy)phenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

4 g of 3-(4-(2-methoxyethoxy)phenoxy)-1,2-epoxypropane, 5.8 g of the sulphate of N-2-aminoethyl-4-morpholinecarboxamide, and 5.8 g of K2CO3 were refluxed in 2-propanol for 2 days. The mixture was filtered and concentrated in vacuo. The residue was dissolved in methylene chloride and washed with H2O. The organic phase was dried over Na2SO4, filtered and evaporated. The product was recrystallized from ethyl acetate. Yield 2.3 g. Melting point 69° C. (base). The structure was determined using NMR and equivalent weight.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue was dissolved in methylene chloride
  4. washwashed with H2O
  5. dry with materialThe organic phase was dried over Na2SO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe product was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-ef615be404514c78b21cfad46faf6846
出典データセット
uspto-grants-1987_01
特許番号
US04636501

反応ノート

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