5-Chloro-2(1H)-pyrimidinone → 5-Chloro-1-(4-methylsulphinylphenacyl)pyrimidin-2-one

HRID 980180ノート

反応式

HRID 980180 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([S:19]([CH3:21])=[O:20])=[CH:15][CH:14]=1)=[O:12]>C(N(CC)CC)C.C(O)C>[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([CH3:21])=[O:20])=[CH:15][CH:14]=2)=[O:12])[CH:7]=1

参加物

5

反応物 2

HCID 1085785-Chloro-2(1H)-pyrimidinoneHCID 127955374-Methylsulphinylphenacyl bromide

生成物 1

HCID 127955465-Chloro-1-(4-methylsulphinylphenacyl)pyrimidin-2-one収率 54.6%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8471Triethylamine溶媒

実験手順

A suspension of 5-chloropyrimidin-2-one (399 mg). and 2-bromo-4'-methylsulphinylacetophenone (784 mg) in triethylamine (1 ml) and ethanol (20 ml) was stirred at ambient temperature for one hour, when the resulting suspension was chilled in ice. The collected solid was crystallised from ethanol to give the title pyrimidinone (509 mg,); m.p. 219°-220°; λmaxEtOH 233.5 nm (ε 17920), 332 nm (ε 2060), λinf 266 nm (ε 9280).

後処理

  1. temperaturewhen the resulting suspension was chilled in ice
  2. customThe collected solid was crystallised from ethanol

出典と根拠

ORDレコード
ord-f6f43282221c4ea9a03bb8905fb42953
出典データセット
uspto-grants-1987_01
特許番号
US04636509

反応ノート

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