Ammonia → HCID 13365190、化合物

HRID 980191

反応式

HRID 980191 の反応式
[OH:1][C:2]1([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[CH2:7][N:6]([CH3:8])[CH2:5][C:4]2[O:9][CH:10]=[CH:11][C:3]1=2.N.B(F)(F)F.[CH3:24]O>>[CH3:24][O:1][C:2]1([C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][CH:13]=2)[CH2:7][N:6]([CH3:8])[CH2:5][C:4]2[O:9][CH:10]=[CH:11][C:3]1=2

参加物

4

反応物 3

HCID 222AmmoniaHCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 13365189HCID 13365189、化合物

生成物 1

HCID 13365190HCID 13365190、化合物

実験手順

Two grams (0.005 mol) of 4-hydroxy-4-(p-bromophenyl)-6-methyl-4,5,6,7-tetrahydro-furano[2,3-c]pyridine were heated to 50° C. for four hours in 40 ml of a boron trifluoride/methanol mixture (20% BF3), and then the mixture was poured onto ice and neutralized with ammonia. The mixture was extracted with ether, and the ether was distilled off in vacuo. The residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)].

後処理

  1. extractionThe mixture was extracted with ether
  2. distillationthe ether was distilled off in vacuo
  3. customThe residue was purified over silica gel [cyclohexane/ethyl acetate (75:25)]

出典と根拠

ORDレコード
ord-45c10db0ae894399ad0c761ab202228d
出典データセット
uspto-grants-1987_01
特許番号
US04636510

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