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1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene → 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,3-Epoxypropoxy)-4-(2-methoxyethoxy)benzene | HCID 12621549 | — |
| 反応物 | 5-(2-Benzylaminopropoxy)salicylamide | HCID 13754334 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]-propan-2-ol | HCID 13754335 | — |
反応手順
A solution of 10.2 g of 1-(2,3-epoxypropoxy)-4-(2-methoxyethoxy)benzene and 11.0 g of 5-[2-(benzylamino)propoxy]salicylamide in 200 ml of isopropanol is refluxed for 24 hours. By concentration of the solution by evaporation, crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-[4-(2-methoxyethoxy)phenoxy]propan-2-ol is obtained as an oil which is used in its crude state for debenzylation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04636511 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-f8dadd52aecc4f6c904d41a27c6255c2 |
| 出典メモ | uspto-grants-1987_01 |