hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid ethyl ester → N-[N,N-diethylamino-ethyl]hexahydro-5-oxo-1H-pyrrolizine-3-carboxamide
反応式
C(O[C:4]([CH:6]1[N:13]2[CH:9]([CH2:10][CH2:11][C:12]2=[O:14])[CH2:8][CH2:7]1)=[O:5])C.C(N[N:18]([CH2:22][CH3:23])NCC)C>>[CH2:12]([N:13]([CH2:23][CH2:22][NH:18][C:4]([CH:6]1[N:13]2[CH:9]([CH2:10][CH2:11][C:12]2=[O:14])[CH2:8][CH2:7]1)=[O:5])[CH2:6][CH3:4])[CH3:11]参加物
3
反応条件
- 温度
- 80 °C
実験手順
A solution of hexahydro-5-oxo-1H-pyrrolizine-3-carboxylic acid ethyl ester (5.0 g, 0.0254 mol) in N,N-diethylaminoethylamine (23.2 g, 0.2 mol) is stirred at room temperature 24 hours and heated at 80° C. for 24 hours. The solution is concentrated at reduced pressure and distilled to yield N-[N,N-diethylamino-ethyl]hexahydro-5-oxo-1H-pyrrolizine-3-carboxamide
後処理
- concentrationThe solution is concentrated at reduced pressure
- distillationdistilled
出典と根拠
- ORDレコード
- ord-96881b4ccff4409baee21829563a7e0a
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04638006
反応ノート
読み込み中…