化工社化工社 化学情報印刷レポート · 研究参考用
Hydroxide → 3-(Pyrazin-2-yl)acrylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydroxide | HCID 961 | — |
| 反応物 | Chloral | HCID 6407 | — |
| 反応物 | 2-Methylpyrazine | HCID 7976 | — |
| 反応物 | 2-(Pyrazin-2-yl)propanoic acid | HCID 17864951 | — |
| 生成物 | 3-(Pyrazin-2-yl)acrylic acid | HCID 305608 | — |
反応手順
Scheme M depicts a specific synthesis of a pyrazinyl propionic acid. Methylpyrazine anion is condensed with trichloroacetaldehyde followed by treatment with base (hydroxide), then acidification to produce 3-(-Pyrazinyl) Acrylic Acid 75. This acid is then catalytically hydrogenated over palladium on charcoal to yield 3-(2-Pyrazinyl)propionic Acid 76.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04638005 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-c13ea9ac38ac4cf591514329645f7d16 |
| 出典メモ | uspto-grants-1987_01 |