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Hydrochloric Acid → 6-Propionyl-3-methyl thiochromane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Propionyl chloride | HCID 62324 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 3-Methyl-thiochromane | HCID 12308537 | — |
| 溶媒 | 1,2-Dichloroethylene | HCID 10900 | — |
| 生成物 | 6-Propionyl-3-methyl thiochromane | HCID 54530528 | — |
反応手順
To 0.13M of AlCl3, 0.12M of propionyl chloride in 150 ml of 1,2-dichloroethylene, 0.1M (16.4 gr.) de 3-methyl-thiochromane are dropwise added at a temperature of ±5° C. After agitating the mixture for 3 hours at room temperature, a mixture of ice and HCl is added and extraction is made with CHCl3. The organic phase is dried on MgSO4, filtered and evaporated. 17.3 gr. of 6-propionyl-3-methyl thiochromane are so obtained, the homogeneity of which is verified by TLC and the structure of which is verified by NMR spectrum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04638070 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-8b058bd4b3774532b9045b91d321daa0 |
| 出典メモ | uspto-grants-1987_01 |