関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | 2,6-Dimethylanisole | HCID 66088 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 4-(3,5-Dimethyl-4-methoxyphenyl)-4-oxobutyric acid | HCID 14032087 | — |
反応手順
Succinic anhydride (22.06 gm) was added to a mixture of 2,6-dimethylanisole (30 g) and anhydrous aluminium trichloride (59 g) in 1,2-dichloroethane (200 ml) at 0° C. The mixture was stirred for 0.5 hr at 0° C. and at room temperature for 4 hr. The mixture was poured onto ice-concentrated hydrochloric acid. After stirring vigorously for 5 min, the mixture was extracted with ethyl acetate. The dried (MgSO4) organic fraction was evaporated to give 4-(3,5-dimethyl-4-methoxyphenyl)-4-oxobutyric acid as white crystals, mp 108° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US04639267 |
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| 出典データセット | uspto-grants-1987_01 |
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| ORD ID | ord-56eeba886a3c4caca4bf9402fed19c29 |
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| 出典メモ | uspto-grants-1987_01 |
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