Triethylamine → HCID 131714665、化合物

HRID 980799ノート

反応式

HRID 980799 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][OH:15])[CH2:12][C:11]2=[CH:16][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl>[S:2]([OH:4])(=[O:7])(=[O:3])[CH3:1].[CH3:6][O:7][C:8]1[CH:9]=[C:10]2[CH:13]([CH2:14][OH:15])[CH2:12][C:11]2=[CH:16][CH:17]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 13247995(4-Methoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanol

生成物 1

HCID 131714665HCID 131714665、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Methane sulphonyl chloride (13.4 ml) is added dropwise to a stirred solution of 5-methoxy-1-hydroxymethyl benzocyclobutene (26 g) and triethylamine (26.5 ml) in methylene chloride (670 ml) cooled to 0° C. under nitrogen. The reaction mixture is allowed to warm to RT, stirred for 2 hours at RT, washed with water and saturated salt, dried over Na2SO4, and filtered. The filtrate is concentrated in vacuo yielding the desired product as a liquid.

後処理

  1. temperatureto warm to RT
  2. washwashed with water and saturated salt
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationThe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-44b4876a464e4f8780c58120eccea4af
出典データセット
uspto-grants-1987_01
特許番号
US04639442

反応ノート

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