4-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine → Cyclohexanone, 4-(4-pyridinyl)-
反応式
C1O[C:4]2([CH2:9][CH2:8][C:7]([C:10]3[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=3)=[CH:6][CH2:5]2)[O:3]C1>Cl.[C].[Pd]>[N:13]1[CH:14]=[CH:15][C:10]([CH:7]2[CH2:6][CH2:5][C:4](=[O:3])[CH2:9][CH2:8]2)=[CH:11][CH:12]=1参加物
4
実験手順
4-(4-Pyridyl)cyclohex-3-enone ethyleneacetal (4 g) was dissolved in 70 ml of 0.5N hydrochloric acid. To the solution, there was added 400 mg of 10% palladium-carbon. Hydrogenation was carried out at room temperature under atmospheric pressure. After removing out the catalyst and adding an aqueous sodium hydroxide solution to alkalify, the reaction mixture was extracted with methylene chloride to obtain 2.7 g of 4-(4-pyridyl)cyclohexanone.
後処理
- customwas carried out at room temperature under atmospheric pressure
- customAfter removing out the catalyst
- additionadding an aqueous sodium hydroxide solution
- extractionthe reaction mixture was extracted with methylene chloride
出典と根拠
- ORDレコード
- ord-0c1e7fc6cc3b428385c4721e4d91775d
- 出典データセット
- uspto-grants-1987_01
- 特許番号
- US04639521
反応ノート
読み込み中…