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Sodium borohydride → 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | Methyl 2-(3-methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylate | HCID 13362002 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one | HCID 13362003 | — |
反応手順
To 26.7 gm. of methyl 2-(3-methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylate in 200 ml of absolute methanol was added slowly at 0°-10° 24.8 gm. of sodium borohydride. The reaction was run and worked up following the procedure of example 1D. Drying (Na2SO4), filtration, and concentration in vacuo provided 17.2 gm. of colorless crystals, m.p. 123°-126°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04639529 |
| 出典データセット | uspto-grants-1987_01 |
| ORD ID | ord-72fa67b9f4c241e4af330b89a58efc1c |
| 出典メモ | uspto-grants-1987_01 |